Because they are mostly a nuisance pest, exclusion is your best bet. Prevent insects from entering gaps in siding, window and door sills, and in soffits or the foundation (it is important to note that screening or mesh fibers may be needed for these openings to prevent insect entry but allow air or water to move through. Sealing soffits or weep holes in ways that prevent airflow can lead to moisture problems). Repair tears in screens. Outdoors, eliminate hiding places and debris, especially around foundations and consider removing female box elder trees (Acer negundo).